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| Fatani,A. J.; Al-Zuhair,H. A.; Yaquob,H. I.; Abdel-Fattah,A. A.; El-Sayed,M. I.; El-Sayed,F. A.. |
| Oxidative stress and proteases have been implicated in several diseases and extensive evidence indicates that antioxidants and protease inhibitors help prevent organ functional damage. Leiurus quinquestriatus (LQQ) scorpion venom causes cellular injuries that may lead to multiple organ failure. Thus, the capability of the antioxidant "natural standardized extract of Gingko biloba leaves (Gin, EGb 761)" and the non-selective protease inhibitor, aprotinin, in ameliorating venom-induced biochemical alterations indicative of cellular injury and oxidative stress was studied to determine their effectiveness in protecting rats from venom-evoked cellular damages. Thus, in this study, rats were treated with LQQ venom (0.3mg.kg-1, subcutaneously) alone or after Gin... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Leiurusquinquestriatus; Ginkgo; Aprotinin; Scorpion venoms. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000200008 |
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| BAGCHI,S.; DESHPANDE,S. B.. |
| The mechanisms underlying the action of Indian red scorpion Buthus tamulus (BT) venom-induced augmentation of cardiopulmonary reflexes elicited by intravenous injection of 5-HT were examined in urethane anaesthetized rats. The 5-HT produced a concentration-dependent increase in time-response area of bradycardiac response, with the responses at submaximal concentrations shifted to the left after exposure to BT venom (20 µg/kg, IV). Aprotinin (6000 kallikrein inactivating unit, IV) as such had no effect on 5-HT reflex responses (bradycardia, hypotension, and apnea), but blocked the venom-induced reflex augmentation. While ondansetron (10 µg/kg, IV) completely blocked the 5-HT reflex responses, these reappeared partially after venom exposure (20 µg/kg).... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bezold-Jarisch reflex; Aprotinin; Bradykinin; Indian red scorpion; Ondansetron; Buthus tamulus; Kinins; 5-HT3 receptors; Cardiopulmonary reflexes. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302001000100003 |
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